Chapter 43 Drugs Used to Treat Cancer

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Chapter 43  Drugs Used to Treat Cancer

 

 

Complete Chapter Questions And Answers
 

Sample Questions

 

MULTIPLE CHOICE

1. The nurse is educating a patient with cancer about combination chemotherapy. Which is an accurate statement?
a.
“Combination chemotherapy is the administration of an antineoplastic drug that will be toxic during a specific phase of cellular growth.”
b.
“Combination chemotherapy is the administration of an antineoplastic drug that is active throughout the cell cycle.”
c.
“Combination chemotherapy is the administration of antineoplastic drugs that change the way the body responds to cancer or strengthens the immune system.”
d.
“Combination chemotherapy is the administration of antineoplastic drugs, which results in cell death during different phases of the cell cycle.”

ANS: D
Use of combination drug therapy is superior in therapeutic effect to the use of single agent chemotherapy.

DIF: Cognitive Level: Comprehension REF: Page 669 OBJ: 1
TOP: Nursing Process Step: Implementation
MSC: NCLEX Client Needs Category: Physiological Integrity
NOT: CONCEPT(S): Clinical Judgment; Patient Education

2. The cell cycle-specific agent vincristine sulphate (Oncovin) acts in which phase of the cell’s life cycle?
a.
S phase
b.
Mitotic phase
c.
Phase G1
d.
Phase G0

ANS: B
Vinca alkaloids block the formation of the mitotic spindle during mitosis, thus inhibiting cell division. The S phase is the stage of active synthesis of two sets of DNA. Phase G1 is considered a presynthetic phase in which the cell prepares for DNA synthesis by manufacturing necessary enzymes. G0 is the largest variable in the cell cycle and, during this resting phase, the cell is not actively replicating.

DIF: Cognitive Level: Knowledge REF: Page 667 | Page 668
OBJ: 1 TOP: Nursing Process Step: Implementation
MSC: NCLEX Client Needs Category: Physiological Integrity
NOT: CONCEPT(S): Clinical Judgment

3. What is the importance of correlating the dosage schedule with cell cycle-specific drug therapy?
a.
Ongoing proliferation of neoplastic tissue
b.
The known cellular kinetics of the neoplasm
c.
The hormonal requirements of the patient
d.
The body’s response in strengthening the immune system

ANS: B
Cell cycle-specific agent scheduling should be correlated with the known cellular kinetics of the particular type of neoplasm being treated. This type of drug is schedule dependent and selectively toxic when the cell is in a specific phase of growth. The object of chemotherapy is to stop the proliferation of neoplastic tissue. Hormones are only used in specific types of cancer and are not related to cell cycle specificity. Immunomodulators are used to enhance the body’s response in strengthening the immune system.

DIF: Cognitive Level: Comprehension REF: Page 669 OBJ: 1
TOP: Nursing Process Step: Implementation
MSC: NCLEX Client Needs Category: Physiological Integrity
NOT: CONCEPT(S): Clinical Judgment

4. When are cancer cells most sensitive to chemotherapy?
a.
Resting phases
b.
Rapid division
c.
Remission intervals
d.
Slow replication

ANS: B
The cancer cells are the most sensitive to chemotherapy when the cells are dividing rapidly. Cancer cells are not sensitive to chemotherapy during resting phases, remission intervals, or slow replication.

DIF: Cognitive Level: Knowledge REF: Page 669 | Page 670
OBJ: 1 TOP: Nursing Process Step: Implementation
MSC: NCLEX Client Needs Category: Physiological Integrity
NOT: CONCEPT(S): Clinical Judgment

5. What is the advantage of combination therapy using cell cycle-specific and cell cycle-nonspecific agents?
a.
Decreased expense and time needed for administration
b.
Decreased toxicity to patients and the nurses who administer the drug
c.
Increased cell death in various cycles and decreased toxicity
d.
Increased rate of treatment success

ANS: D
Combination therapy is far superior to the use of single agent therapy. The use of a cell cycle-specific and cell cycle-nonspecific agents together facilitates cell death during different phases of the cell cycle. Combination therapy is not more economical or faster. Combination therapy is not less toxic because it exposes patients and nurses to additional medications. The use of combination drug therapy allows for cell death during different phases of the cell cycle, but the agents often have toxic effects on different organs at different time intervals after administration.

DIF: Cognitive Level: Comprehension REF: Page 669 OBJ: 2
TOP: Nursing Process Step: Evaluation
MSC: NCLEX Client Needs Category: Physiological Integrity
NOT: CONCEPT(S): Clinical Judgment

 

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