Chapter 30 Drug Therapy to Decrease Histamine Effects


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Chapter 30  Drug Therapy to Decrease Histamine Effects



Complete chapter Questions And Answers

Sample Questions



1. A patient is stung by a bee. What is the chemical mediator released in immune and inflammatory response to the bee sting?

  1. A)  Norepinephrine
  2. B)  Mast cells
  3. C)  Epinephrine
  4. D)  Histamine

Ans: D
Histamine is the chemical mediator released in immune and inflammatory response to the bee sting.

2. A patient is experiencing allergy symptoms after being exposed to environmental dust. This reaction involves the action of histamine, which is released by what cells?

  1. A)  Lymphocytes
  2. B)  CD4 T cells
  3. C)  Basophils
  4. D)  Platelets

Ans: C
Histamine is discharged from mast cells and basophils in response to certain stimuli, such as allergic reactions, cellular injury, and extreme cold. Lymphocytes and platelets do not release histamine.

3. A patient is being administered epinephrine for the treatment of anaphylaxis. This patient is experiencing what type of hypersensitivity reaction?

  1. A)  TypeI
  2. B)  Type II
  3. C)  Type III
  4. D)  Type IV

Ans: A
Anaphylaxis is a type I response, which can be mild or life threatening.

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4. An elderly patient is given diphenhydramine (Benadryl) for allergic response to mold. The nurse should consequently assess the patient for

  1. A)  anticholinergic effects.
  2. B)  dysrhythmias.
  3. C)  increased muscle tone.
  4. D)  respiratory depression.

Ans: A
Diphenhydramine (Benadryl) is the prototype of first-generation antihistamines and causes a high incidence of drowsiness and anticholinergic effects. It is not associated with dysrhythmias, increased muscle tone, or respiratory depression.

5. A second-generation H1 receptor antagonist antihistamine formulated as a nasal spray for topical use is

  1. A)  chlorpheniramine (Chlor-Trimeton).
  2. B)  clemastine (Tavist).
  3. C)  cyproheptadine (Periactin).
  4. D)  azelastine (Astelin).

Ans: D Feedback:

Azelastine (Astelin) and olopatadine (Patanol) are second-generation H1 receptor antagonists that have been formulated as nasal sprays for topical use. Each of the other listed drugs is a first-generation H1 receptor antagonist.

6. A patient is instructed to take diphenhydramine (Benadryl) after an allergic reaction. Which of the following statements by the patient indicates successful teaching concerning the safe and effective use of diphenhydramine?

  1. A)  “I will still be able to have my after-dinner drink with this medication.”
  2. B)  “I will eat a diet low in sodium while taking this medication.”
  3. C)  “I should not drive my car after taking this medication.”
  4. D)  “I can take this medication every 2 hours until I feel better.”

Ans: C


The administration of diphenhydramine (Benadryl) causes drowsiness, and the patient should not operate machinery, such as driving. The patient should not combine diphenhydramine with alcohol due to central nervous system depression. The patient will not need to limit sodium with this medication. The patient should adhere to the dosing schedule and not take the medication every 2 hours.

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