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Sample Questions Posted Below
Chapter 05
Histology
True / False Questions
- Mesoderm gives rise to muscle, bone, and blood.
- Columnar cells lining the small intestine have a brush border of microvilli on the apical surface.
- Nonkeratinized cells exfoliate from the surface of the skin.
- In an epithelium, there is almost no extracellular matrix.
- The clear gel that usually surrounds cells is called interstitial fluid.
- Fibrocartilage is found in intervertebral discs.
- Blood consists of cells and a ground substance made of formed elements.
- Plasma cells produce the ground substance that forms the matrix of connective tissues.
- Excitable cells respond to outside stimuli by means of changes in plasma membrane shape.
- Smooth and cardiac muscles are under involuntary control.
- Dendrites in a neuron send outgoing signals to other cells.
- Desmosomes are more effective than tight junctions in preventing substances from passing between cells.
- The duct of an endocrine gland leads into the bloodstream rather than onto an epithelial surface.
- The secretory product of a gland is produced by its parenchyma, not its stroma.
- Scar tissue helps to hold an organ together but does not restore normal function of the damaged tissue.
Multiple Choice Questions
- The four primary tissue types found in adult organs include all of the following except _________ tissue.
- connective
- fibrous
- nervous
- epithelial
- muscular
- The __________ gives rise to the __________.
- mesoderm; digestive glands
- endoderm; muscular system and skeletal system
- ectoderm; nervous system and epidermis
- endoderm; mesoderm
- mesoderm; endoderm
- The clear gel inside a cell is called __________.
- matrix
- ground substance
- interstitial fluid
- cytosol
- tissue fluid
- A thin, stained slice of tissue mounted on a microscope is called a __________.
- fixative
- histological section
- spread
- stain
- smear
- The histological section that divides a specimen along its long axis is called a(n) __________ section.
- cross
- oblique
- transverse
- sagittal
- longitudinal
- The covering of body surfaces and the lining of body cavities is composed of __________ tissue.
- interstitial
- muscle
- adipose
- epithelial
- nervous
- An epithelium whose cells are tall and narrow, with each one touching the basement membrane and reaching the apical surface, is called __________ epithelium.
- stratified squamous
- stratified cuboidal
- simple cuboidal
- simple columnar
- pseudostratified columnar
- The basement membrane is found between __________ and __________.
- epithelium; connective tissue
- epithelium; extracellular material
- epithelium; intracellular material
- extracellular material; intracellular material
- interstitial fluid; extracellular fluid
- Rapid diffusion of oxygen and carbon dioxide through the air sacs (alveoli) of the lungs takes place through __________ epithelium.
- simple squamous
- simple cuboidal
- simple columnar
- keratinized stratified squamous
- nonkeratinized stratified squamous
- Most kidney tubules are made of __________ epithelial tissue, which is specialized for absorption and secretion.
- simple columnar
- stratified columnar
- pseudostratified columnar
- simple cuboidal
- stratified cuboidal
- __________ epithelium is the most widespread epithelium in the body, whereas __________ epithelium is rare.
- Simple columnar; stratified columnar
- Stratified squamous; stratified columnar
- Pseudostratified; stratified squamous
- Simple cuboidal; stratified squamous
- Stratified squamous; simple squamous
- Some simple columnar and pseudostratified columnar epithelia have _________ cells, which produce a protective mucous coating over the mucous membranes.
- fibrous
- blood
- basal
- keratinized
- goblet
- A brush border of microvilli is found in __________ epithelium, which can be found in the __________.
- pseudostratified; nasal cavity
- simple cuboidal; esophagus
- simple columnar; small intestine
- stratified squamous; anal canal
- stratified squamous; esophagus
- All cells in _______ epithelium reach the basement membrane, but only cells that reach the free surface have cilia.
- pseudostratified columnar
- simple columnar
- stratified columnar
- stratified cuboidal
- stratified squamous
- Found in the urinary bladder, __________ epithelium resembles __________ epithelium, but the apical cells are rounded, not flattened.
- transitional; stratified squamous
- stratified squamous; pseudostratified
- stratified squamous; stratified columnar
- simple columnar; pseudostratified
- transitional; simple cuboidal
- __________ epithelium provides a moist and slippery surface and is well suited to resist stress, as seen in the __________.
- Transitional; tongue
- Keratinized; tongue
- Nonkeratinized; skin
- Keratinized; skin
- Nonkeratinized; vagina
- __________ epithelium is associated with rapid transport of substances through a membrane, whereas __________ epithelium is associated with resistance to abrasion.
- Simple columnar; transitional
- Simple squamous; stratified squamous
- Simple cuboidal; pseudostratified
- Pseudostratified; simple squamous
- Pseudostratified; simple cuboidal
- Which of the following is not a feature that almost all connective tissues have in common?
- Most cells are not in direct contact with each other.
- Ground substance is so scarce that it is not visible with a light microscope.
- Cells usually occupy less space than the extracellular material.
- Protein fibers are usually present in the ground substance.
- Most connective tissues are highly vascular.
- An example of a highly vascular tissue is __________ tissue. An example of a tissue that is not highly vascular is __________.
- epithelial; cartilage
- muscular; osseous tissue
- dense regular connective; dense irregular connective tissue
- areolar; cartilage
- nervous; osseous tissue
- Which of the following is not a feature that connective tissues have in common?
- Very conspicuous fibers
- The presence of fibroblasts
- The presence of collagen
- Ground substance with a gelatinous to rubbery consistency
- A calcified matrix
- The shape of a person’s external ear is due to the presence of __________.
- dense regular connective tissue
- dense irregular connective tissue
- elastic cartilage
- fibrocartilage
- ligaments
- Which of the following is not a type of fibrous connective tissue?
- Reticular tissue
- Hyaline cartilage
- Dense regular connective tissue
- Dense irregular connective tissue
- Areolar tissue
- New triglycerides are constantly being synthesized and stored, while others are hydrolyzed and released into the circulation by the cells found in __________.
- blood
- fibrous connective tissue
- adipose tissue
- reticular tissue
- transitional tissue
- The rubbery matrix of cartilage is secreted by __________, whereas _________ produce the fibers and ground substance that form the matrix of fibrous connective tissue.
- chondroblasts; plasma cells
- mast cells; fibroblasts
- osteocytes; chondroblasts
- chondroblasts; fibroblasts
- adipocytes; plasma cells
- Marfan syndrome is a hereditary defect of elastin fibers. People with this syndrome have __________.
- hyperextensible joints
- a small cranium
- elastic bones
- stronger bones
- viscous blood
- Which of the following does not account for the gelatinous consistency of connective tissue ground substance?
- Glycosaminoglycans (GAGs)
- Proteoglycans
- Chondroitin sulfate
- Hyaluronic acid
- Collagen
- Collagenous fibers are very abundant in __________.
- blood and hyaline cartilage
- blood, adipose tissue, and osseous tissue
- ligaments, bones, and the most superficial portion of the skin
- tendons, ligaments, and the deeper portion of the skin
- areolar tissue, tongue, and bones
- Fibroblasts and protein fibers are associated with both __________ and __________.
- dense regular; dense irregular connective tissues
- plasma; formed elements
- elastic cartilage; hyaline cartilage
- spongy bone; compact (dense) bone
- adipose tissue; reticular tissue
- Glycosaminoglycans (GAGs) help give the ground substance some of its qualities, including _________.
- helping to transfer charges in the nervous system
- holding water and maintaining electrolyte balance
- giving bone its brittle, inorganic structure
- providing the major structural support of tendons and ligaments
- acting as an energy reserve for muscle contraction
- Blood functions to __________________.
- allow for heart contraction and relaxation
- store energy for the heart
- provide support to the heart
- line the heart chambers
- transport nutrients to the tissues
- __________________ exhibits a lot of apparently empty space, and is found in many serous membranes.
- Blood
- Areolar tissue
- Osseous tissue
- Dense irregular connective tissue
- Adipose tissue
- __________________ tissues respond quickly to outside stimuli by means of changes in membrane potential.
- Excitable
- Responsive
- Adipose
- Epithelial
- Connective
- Nervous tissue consists predominantly of two cell types, neurons and __________.
- fibroblasts
- chondrocytes
- neuroglia
- myocytes
- osteocytes
- Astronauts in zero gravity are able to move food through their digestive tracts because __________.
- smooth muscle produces waves of contractions that propel material through the digestive tract
- skeletal muscle puts pressure on the digestive tract
- cardiac muscle maintains a high pressure that moves material through the digestive tract
- striated muscle creates a pressure gradient that forces material from one end of the digestive tract to the other
- skeletal muscle sphincters contract and allow materials to move through the digestive tract
- Skeletal muscle is described as __________.
- striated and voluntary
- striated and involuntary
- nonstriated and voluntary
- nonstriated and involuntary
- fibrous and containing ground substance
- A connective tissue fiber refers to a(n) __________, a nerve fiber refers to a(n) __________, and a muscle fiber refers to a(n) __________.
- entire cell; organelle; tissue
- organelle; entire cell; part of a cell
- organelle; entire cell; complex of macromolecules
- complex of macromolecules; entire cell; part of a cell
- complex of macromolecules; part of a cell; entire cell
- In the intestine, __________ ensure(s) that most digested nutrients pass through the epithelial cells and not between them.
- the plasma membrane
- desmosomes
- tight junctions
- gap (communicating) junctions
- ground substance
- __________ secrete __________ into __________.
- Goblet cells; mucus; the blood
- Endocrine glands; hormones; ducts
- Exocrine glands; hormones; ducts
- Endocrine glands; hormones; the blood
- Exocrine glands; mucus; the blood
- Mucin is secreted by__________ glands, which combines with water to form a thick and sticky product. _________ glands produce a relatively watery fluid.
- mucous; serous
- merocrine; holocrine
- apocrine; mixed
- endocrine; exocrine
- serous; mucous
- __________ glands (such as tear glands) have vesicles that release their secretion via exocytosis. __________ glands (such as oil-producing glands) secrete a mixture of disintegrated cells and their products.
- Endocrine; Exocrine
- Mucous; Serous
- Cytogenic; Apocrine
- Mucous; Cutaneous
- Merocrine; Holocrine
- Glands that have branched ducts and secretory cells that form sacs at one end of the ducts are classified as ___________ glands.
- areolar
- simple acinar
- simple coiled tubular
- compound acinar
- compound tubuloacinar
- The membrane that lines the lumenal surfaces of the digestive, respiratory, urinary, and reproductive tracts consists of _________.
- simple squamous epithelium and dense irregular connective tissue
- areolar and dense irregular connective tissue
- epithelium and lamina propria
- areolar tissue and lamina propria
- simple squamous epithelium and areolar tissue
- Most membranes are composed of two or three tissue types. However, an example of an exception is the ___________ membrane.
- mucous
- serous
- synovial
- cutaneous
- basement
- The membrane that lines passageways that open to the exterior environment is called __________.
- the lamina propria
- endothelium
- a synovial membrane
- a serous membrane (serosa)
- a mucous membrane (mucosa)
- After six months of lifting weights at the gym, you notice that some of your muscles have increased in size. This increase in size is due to __________ of muscle cells.
- hyperplasia
- neoplasia
- hypertrophy
- metaplasia
- atrophy
- The middle primary germ layer is called __________, which gives rise to a gelatinous material called __________, which then gives rise to different types of connective tissue such as bone, muscle, and blood.
- ectoderm; stem cells
- mesoderm; mesenchyme
- endoderm; mesenchyme
- mesoderm; fibroblasts
- ectoderm; mesenchyme
- Most biologists see embryonic stem (ES) cells as a possible treatment for diseases that result from the loss of functional cells. This possibility is based on the fact that ES cells are __________ stem cells.
- unipotent
- multipotent
- pluripotent
- totipotent
- omnipotent
- The pseudostratified columnar epithelium of the bronchi in smokers may transform into stratified squamous epithelium. This is an example of __________.
- neoplasia
- metaplasia
- atrophy
- differentiation
- hyperplasia
- With regard to the healing of a skin wound, macrophages ___________.
- release histamine to increase blood flow to the area
- produce and secrete collagenous fibers
- phagocytize and digest tissue debris
- stimulate epithelial cells to multiply
- make capillaries more permeable allowing white blood cells to migrate into the area
- It is normal for breasts to shrink after lactation ceases. This is a consequence of __________ in human breast cells.
- necrosis
- apoptosis
- atrophy
- infarction
- gangrene
- The replacement of damaged tissue with scar tissue is called _________.
- necrosis
- apoptosis
- gangrene
- regeneration
- fibrosis
Chapter 18
The Circulatory System: Blood
True / False Questions
- Hemostasis is the production of formed elements of blood.
- Blood viscosity stems mainly from electrolytes and monomers dissolved in plasma.
- Lymphoid hemopoiesis occurs mainly in the bone marrow.
- Oxygen and carbon dioxide bind to different parts of hemoglobin.
- The liver stores excess iron in ferritin.
- The most important components in the cytoplasm of RBCs are hemoglobin and carbonic anhydrase.
- A person develops anti-A antibodies only after he is exposed to antigen A, and anti-B antibodies only after he is exposed to antigen B.
- Incompatibility of one person’s blood with another results from the action of plasma antibodies against the RBCs’ antigens.
- Rh incompatibility between a sensitized Rh+ woman and an Rh- fetus can cause hemolytic disease of the newborn.
- Circulating WBCs spend most of their lives in the bloodstream.
- Lymphocytes secrete antibodies, coordinate action of other immune cells, and serve in immune memory.
- Monocytes differentiate into large phagocytic cells.
- Coagulation starts with a vascular spasm and ends with the formation of a platelet plug.
- Clotting deficiency can result from thrombocytopenia or hemophilia.
- After a wound is sealed, tissue repair is followed by fibrinolysis.
Multiple Choice Questions
- Which of the following is not a function of blood?
- Transports a variety of nutrients
- Helps to stabilize the pH of extracellular fluids
- Participates in the initiation of blood clotting
- Produces plasma hormones
- Helps to regulate body temperature
- Which of the following is not contained in the buffy coat?
- Lymphocytes
- Granulocytes
- Erythrocytes
- Agranulocytes
- Platelets
- A normal hematocrit is __________ of the total blood volume.
- less than 1%
- 47% to 63%
- 25% to 37%
- 42% to 45%
- 37% to 52%
- Which of the following is not normally found in plasma?
- Glycogen
- Fibrinogen
- Glucose
- Urea
- Albumin
- Which of the following proteins is not normally found in plasma?
- Albumin
- Hemoglobin
- Transferrin
- Prothrombin
- Fibrinogen
- What is the most abundant protein in plasma?
- Insulin
- Creatine
- Bilirubin
- Albumin
- Creatinine
- Which of the following would not decrease the blood colloid osmotic pressure (COP)?
- Severe liver failure
- A diet predominantly based on red meat
- Starvation
- An extremely low-protein diet
- Hypoproteinemia
- Serum is essentially identical to plasma except for the absence of __________.
- fibrinogen
- nitrogenous wastes
- platelets
- glucose
- albumin
- Tissues can become edematous (swollen) when which of the following occurs?
- Colloid osmotic pressure (COP) is high.
- There is hyperproteinemia.
- The concentration of sodium and proteins in blood is high.
- The hematocrit is high.
- There is a dietary protein deficiency.
- Where does myeloid hemopoiesis take place in adults?
- Thymus
- Spleen
- Red bone marrow
- Yellow bone marrow
- Liver
- The viscosity of blood is due more to the presence of __________ than to any other factor.
- fibrin
- albumin
- sodium
- erythrocytes
- nitrogenous wastes
- Erythrocytes transport oxygen and __________.
- defend the body against pathogens
- initiate blood clotting
- regulate erythropoiesis
- transport nutrients
- transport some carbon dioxide
- Most oxygen is transported in the blood bound to __________.
- the plasma membrane of erythrocytes
- alpha chains in hemoglobin
- beta chains in hemoglobin
- delta chains in hemoglobin
- heme groups in hemoglobin
- What would happen if all of the hemoglobin contained within the RBCs became free in the plasma?
- It would considerably increase blood oxygen carrying capacity.
- It would facilitate delivery of oxygen into tissues supplied by small capillaries.
- It would facilitate oxygen diffusion into cells distant from blood capillaries.
- It would significantly increase blood osmolarity.
- It would drastically increase osmotic colloid pressure.
- An increased erythropoietin (EPO) output by the kidneys would lead to all of the following except __________.
- increased hypoxemia
- increased blood osmolarity
- increased RBC production
- increased blood viscosity
- increased hematocrit
- Where do most RBCs die?
- Stomach and small intestine
- Red bone marrow
- Spleen and liver
- Lymph nodes and thymus
- Stomach and liver
- Which of the following would not lead to polycythemia?
- Cancer of the erythropoietic line of the red bone marrow
- Iron deficiency
- Dehydration
- Emphysema
- Excessive aerobic exercise
- Which of the following is most likely to cause anemia?
- High altitude
- Air pollution other than by carbon monoxide
- Renal disease
- Smoking
- Any factor that creates a state of hypoxemia
- Which of the following is not true of a patient with anemia?
- Their blood viscosity is increased.
- They are lethargic.
- Their blood osmolarity is reduced.
- Their resistance to blood flow is reduced.
- More fluid transfers from their bloodstream into their intercellular spaces.
- What is the final product of the breakdown of the organic nonprotein moiety of hemoglobin?
- Biliverdin
- Bilirubin
- Globin
- Heme
- Iron
- Correction of hypoxemia is regulated by __________.
- a self-amplifying mechanism
- an enzymatic amplification
- a positive feedback loop
- a negative feedback loop
- a cascade effect
- A deficiency of __________ can cause pernicious anemia.
- vitamin C
- iron
- vitamin B12
- EPO secretion
- folic acid
- Which of the following is not true regarding sickle-cell disease?
- It is caused by a recessive allele that modifies the structure of hemoglobin.
- It is due to a hereditary hemoglobin defect.
- It is advantageous in that it can protect carriers against malaria.
- It is a cause of malaria.
- It is a cause of anemia.
- The ABO blood group is determined by __________ in the plasma membrane of RBCs.
- glycolipids
- glycoproteins
- antibodies
- antigen-antibody complexes
- agglutinins
- A person with type A blood can safely donate RBCs to someone of type __________ and can receive RBCs from someone of type __________.
- O; AB
- AB; O
- A; B
- B; A
- O; O
- A person with type AB blood has __________ RBC antigen(s).
- no
- anti-A and anti-B
- anti-A
- anti-B
- A and B
- Why are pregnant Rh- women given an injection of Rh immune globulin?
- Antibodies in the injection bind fetal RBC antigens so they cannot stimulate her immune system to produce anti-D antibodies.
- Antibodies in the injection bind fetal RBC antigens so they cannot stimulate her immune system to produce anti-A and anti-B antibodies.
- Antibodies in the injection bind fetal RBC antigens so they cannot stimulate her immune system to produce anti-A antibodies.
- Antibodies in the injection bind fetal RBC antigens so they cannot stimulate her immune system to produce anti-O antibodies.
- Antibodies in the injection bind fetal RBC antigens so they cannot stimulate her immune system to produce anti-B antibodies.
- The universal donor of RBCs, but not necessarily plasma, is blood type __________.
- AB, Rh-negative
- AB, Rh-positive
- O, Rh-negative
- O, Rh-positive
- ABO, Rh-negative
- An individual has type B, Rh-positive blood. The individual has __________ antigen(s) and can produce anti-__________ antibodies.
- A and D; B
- B and D; A
- B; A and D
- A; B and D
- D; A and B
- The main reason why an individual with type AB, Rh-negative blood cannot donate blood to an individual with type A, Rh-positive blood is because __________.
- anti-A antibodies in the donor will agglutinate RBCs of the recipient
- anti-A antibodies in the recipient will agglutinate RBCs of the donor
- anti-B antibodies in the donor will agglutinate RBCs of the recipient
- anti-D antibodies in the donor will agglutinate RBC of the recipient
- anti-B antibodies in the recipient will agglutinate RBCs of the donor
- A woman’s first pregnancy is normal but her second pregnancy results in hemolytic disease of the newborn (HDN). The second child needed a transfusion to completely replace the agglutinating blood. The mother is most likely type __________ and both children are most likely __________.
- A, Rh-negative; B, Rh-positive
- A, Rh-positive; B, Rh-negative
- O, Rh-negative; AB, Rh-negative
- AB, Rh-positive; O, Rh-negative
- AB, Rh-positive; O, Rh-positive
- What are the least abundant of the formed elements?
- Platelets
- Basophils
- Erythrocytes
- Neutrophils
- Eosinophils
- What are the most abundant agranulocytes?
- Macrophages
- Eosinophils
- Monocytes
- Lymphocytes
- Neutrophils
- The number of __________ typically increases in response to bacterial infections.
- basophils
- monocytes
- erythrocytes
- eosinophils
- neutrophils
- Which cells aid in the body’s defense processes by secreting histamine and heparin?
- Eosinophils
- Basophils
- Neutrophils
- Platelets
- Monocytes
- Leukopoiesis begins with the differentiation of __________.
- pluripotent stem cells
- precursor cells
- colony-forming units
- myeloblasts
- lymphoblasts
- Some lymphocytes can survive as long as __________.
- days
- weeks
- months
- years
- decades
- A patient is diagnosed with leukocytosis if they have more than __________ WBCs/L.
- 100,000
- 50,000
- 10,000
- 5,000
- 1,000
- Which of the following has not been implicated in causing leukemia?
- Acquired Immunodeficiency Syndrome (AIDS)
- Lead poisoning
- Radiation therapy
- Dehydration
- Immunosuppressant drugs
- What is the largest leukocyte that contains small cytoplasmic granules and typically a kidney- or horseshoe-shaped nucleus?
- Monocyte
- Lymphocyte
- Neutrophil
- Eosinophil
- Basophil
- Which of the following are not secreted by platelets?
- Procoagulants
- Thrombopoietin
- Growth factors
- Vasoconstrictors
- Chemicals that attract neutrophils
- The cessation of bleeding is specifically called __________.
- a vascular spasm
- homeostasis
- hemostasis
- platelet plug formation
- coagulation
- What is the function of thromboplastin in hemostasis?
- It initiates the intrinsic pathway of coagulation.
- It initiates the extrinsic pathway of coagulation.
- It converts prothrombin into thrombin.
- It acts as a potent vasoconstrictor to reduce blood loss.
- It dissolves the clot after the tissue has healed.
- When a clot is no longer needed, fibrin is dissolved by __________.
- prothrombin
- thromboplastin
- kallikrein
- plasmin
- platelet-derived growth factor
- Which of these does not prevent the spontaneous formation of a clot?
- The presence of tissue thromboplastin
- The smooth prostacyclin-coated endothelium of blood vessels
- The dilution of thrombin when blood flows at a normal rate
- The presence of antithrombin in plasma
- The presence of heparin in plasma
- Platelets release __________, a chemical vasoconstrictor that contributes to the vascular spasm.
- heparin
- thrombin
- thromboplastin
- prostacyclin
- serotonin
- The structural framework of a blood clot is formed by __________.
- soluble fibrinogen
- soluble fibrin
- a fibrin polymer
- a fibrinogen polymer
- a thrombin polymer
- Most strokes and heart attacks are caused by the abnormal clotting of blood in an unbroken vessel. Moreover, a piece of the __________ (clot) may break loose and begin to travel in the bloodstream as a(n) __________.
- thrombus; embolus
- embolism; thrombus
- plaque; thrombus
- thrombosis; plaque
- plaque; embolus
- During coagulation, which of the following is found in the extrinsic mechanism only?
- Calcium
- Prothrombin activator
- Prothrombin
- Thromboplastin
- Thrombin
- Where are most clotting factors synthesized in the body?
- Spleen
- Red bone marrow
- Perivascular tissue
- Kidneys
- Liver
- A patient is suffering from ketoacidosis caused by an unregulated high protein diet. Which function of the blood has been compromised?
- Stabilizing fluid distribution in the body
- Stabilizing the body’s pH
- Protecting against microorganisms
- Transporting nutrients
- Transporting hormones
- Where in the body are hemopoietic stem cells found?
- Yellow bone marrow
- Thymus
- Red bone marrow
- Spleen
- Liver
- Which of the following might be injected into a patient who is prone to forming blood clots and therefore at risk of a heart attack or stroke?
- Thromboplastin
- Fibrinogen
- Fibrin
- Heparin
- Factor X
- Blood clots in the limbs put a patient most at risk for __________.
- hemophilia
- pulmonary embolism
- thrombocytopenia
- disseminated intravascular coagulation (DIC)
- septicemia
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