Chapter 7 Methods of Calculation for Individualized Drug Dosing

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Chapter 7  Methods of Calculation for Individualized Drug Dosing

 

 

Complete Chapter Questions And Answers
 

Sample Questions

 

Body Surface Area by Square Root

1. Order: cyclophosphamide 500 mg/m2 in 500 mL of normal saline solution (NSS) over 90 minutes
Patient height and weight: 5 ft 10 in, 142 lb
Drug available: cyclophosphamide 100 mg dilute with 5 mL of sterile water; yields 20 mg/mL
a. What is the patient’s body surface area (BSA) (m2)?
b. What is the total dose?
c. How many milliliters should you prepare?

ANS:
a.

b. 500 mg/m2 × 1.78 m2 = 890 mg

c. FE: 890 mg/100 mg × 5 mL = 44.5 mL

OR

2. Order: cisplatin 50 mg/m2 in 500 mL of NSS intravenously over 90 minutes
Patient height and weight: 5 ft 6 in, 160 lb
Drug available: cisplatin 100 mg/100 mL
a. What is the patient’s BSA (m2)?
b. What is the total dose?
c. How many milliliters should you prepare?

ANS:
a.

b.50 mg × 1.83 m2 = 91.5 mg

c. FE: 91.5 mg/100 mg × 100 mL = 91.5 mL or 92 mL

OR

For Questions 3 through 18, use the square root method and/or nomogram. Note discrepancies between methods.

3. Give dacarbazine 250 mg/m2/day × 5 days.
Patient height: 5 ft 10 in
Patient weight: 173 lb
What is the daily dose with:
a. square root method?
b. nomogram?

ANS:
a.
250 mg/m2/day × 1.96 m2 = 490 mg/day

b. Height 70 in, weight 173 lb, intersects 2.02 m2
250 mg/m2/day × 2.02 m2 = 505 500 mg/day

4. Give 5-fluorouracil 450 mg/m2/wk.
Patient height: 5 ft 6 in
Patient weight: 210 lb
What is the weekly dose with:
a. square root method?
b. nomogram?

ANS:
a.
450 mg/m2/wk × 2.10 m2 = 945 mg/wk

b. Height 66 in, weight 210 lb, intersects 2.04 m2
450 mg/m2/wk × 2.04 m2 = 918 920 mg/wk

5. Give leucovorin 200 mg/m2/wk.
Patient height: 5 ft 6 in
Patient weight: 210 lb
What is the weekly dose with:
a. square root method?
b. nomogram?

ANS:

80 kg x 2.2 = 176 lb

a.
200 mg/m2/wk × 2.10 m2 = 420 mg/wk
b. Height 66 in, weight 210 lb, intersects 2.04 m2
200 mg/m2/wk × 2.04 m2 = 408.00 400 mg/wk

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