Chapter 11 Drug Therapy to Suppress Immunity


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Chapter 11  Drug Therapy to Suppress Immunity


Complete chapter Questions And Answers

Sample Questions



1. Which of the following is the most likely indication for the use of immunosuppressant agents?

  1. A)  Intractable seizure disorders
  2. B)  Increased intracranial pressure
  3. C)  Organ transplantation
  4. D)  HIV/AIDS with multiple drug resistance

Ans: C
Immunosuppressant agents are used for inflammatory autoimmune disorders or to prevent or treat tissue rejection reactions in organ transplantation. Immunosuppressant agents are not administered for seizure disorders, increased intracranial pressure, or HIV/AIDS.

2. A patient has received a bone marrow transplant. What will occur if the patient receives inadequate immunosuppression after the transplant?

  1. A)  Graft-versus-host disease
  2. B)  Hepatotoxicity
  3. C)  Acute kidney injury
  4. D)  Sepsis

Ans: A Feedback:

The goal after bone marrow transplantation is to provide adequate immunosuppression. If immunosuppression is inadequate, graft-versus-host disease will occur with bone marrow transplantation. The patient will not suffer from hepatic or renal failure. Inadequate immunosuppression will not place the patient at risk for serious infection.

3. A patient with Crohn’s disease is given a corticosteroid to decrease inflammation. Which of the following effects will occur with the use of corticosteroids?

  1. A)  Increased joint pain
  2. B)  Increased C-reactive protein levels
  3. C)  Increased T-cell counts
  4. D)  Decreased antibody production

Ans: D
The administration of corticosteroids will decrease T-cell and antibody production. Corticosteroids do not cause joint pain or increase a patient’s C-reactive protein levels.

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4. A patient is to begin treatment for rheumatoid arthritis with infliximab (Remicade). What potential risk should the nurse identify as being associated with this drug?

  1. A)  Risk for infection
  2. B)  Risk for decreased level of consciousness
  3. C)  Risk for nephrotoxicity
  4. D)  Risk for hepatotoxicity

Ans: A Feedback:

All TNF-alpha blockers carry a risk for infection. This risk supersedes the risks of kidney or liver damage. Changes in LOC are not typically noted.

5. A patient is administered mycophenolate (CellCept) to prevent rejection of his transplanted heart. It is recommended that he have a CBC drawn weekly. He asks the nurse the reason for the weekly CBC. Which of the following is the nurse’s best response?

  1. A)  “The weekly CBC is routine and ordered for all patients.”
  2. B)  “The weekly CBC assesses for the development of bleeding.”
  3. C)  “The weekly CBC assesses for the development of infection.”
  4. D)  “The weekly CBC assesses for changes in your blood’s oxygen carrying


Ans: C


The weekly CBC is to assess for infection, neutropenia, and thrombocytopenia. Stating to the patient that the CBC is routine is a belittling response that does not provide patient education. The weekly CBC is not indicated to assess for bleeding or a decrease in erythrocytes.

6. A patient is administered cyclosporine (Sandimmune, Neoral) to prevent rejection of a kidney transplant. Which of the following is a major adverse effect of cyclosporine?

  1. A)  Congestive heart failure
  2. B)  Nephrotoxicity
  3. C)  Anaphylaxis
  4. D)  Respiratory arrest

Ans: B
The major adverse effect of cyclosporine is nephrotoxicity. Congestive heart failure is not noted as an adverse effect of cyclosporine. Anaphylaxis and respiratory arrest are not common adverse effects of cyclosporine.

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