Clinical Calculations With Applications to General And Specialty Areas 7th Edition by Joyce – Sally M. – Test Bank

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Chapter 7: Methods of Calculation for Individualized Drug Dosing

OTHER

Body Surface Area by Square Root

1.Order: cyclophosphamide 500 mg/m² in 500 mL of normal saline solution (NSS) over 90 minutes

Patient height and weight: 5 ft 10 in, 142 lb

Drug available: cyclophosphamide 100 mg dilute with 5 mL of sterile water; yields 20 mg/mL

a. What is the patient’s body surface area (BSA) (m²)?

b. What is the total dose?

c. How many milliliters should you prepare?

ANS:

a. 

b. 500 mg/m² × 1.78 m² = 890 mg

c. FE: 890 mg/100 mg × 5 mL = 44.5 mL  

OR 

2.Order: cisplatin 50 mg/m² in 500 mL of NSS intravenously over 90 minutes

Patient height and weight: 5 ft 6 in, 160 lb

Drug available: cisplatin 100 mg/100 mL

a. What is the patient’s BSA (m²)?

b. What is the total dose?

c. How many milliliters should you prepare?

ANS:

a. 

b.50 mg × 1.83 m² = 91.5 mg

c.  FE: 91.5 mg/100 mg × 100 mL = 91.5 mL or 92 mL  

OR 

For Questions 3 through 18, use the square root method and/or nomogram. Note discrepancies between methods.

3.Give dacarbazine 250 mg/m²/day × 5 days.

Patient height: 5 ft 10 in

Patient weight: 173 lb

What is the daily dose with:

a. square root method?

b. nomogram?

ANS:

a. 

250 mg/m²/day × 1.96 m² = 490 mg/day

b. Height 70 in, weight 173 lb, intersects 2.02 m²

250 mg/m²/day × 2.02 m² = 505  500 mg/day

4.Give 5-fluorouracil 450 mg/m²/wk.

Patient height: 5 ft 6 in

Patient weight: 210 lb

What is the weekly dose with:

a. square root method?

b. nomogram?

ANS:

a. 

450 mg/m²/wk × 2.10 m² = 945 mg/wk

b. Height 66 in, weight 210 lb, intersects 2.04 m²

450 mg/m²/wk × 2.04 m² = 918  920 mg/wk

5.Give leucovorin 200 mg/m²/wk.

Patient height: 5 ft 6 in

Patient weight: 210 lb

What is the weekly dose with:

a. square root method?

b. nomogram?

ANS:

80 kg x 2.2 = 176 lb

a. 

200 mg/m²/wk × 2.10 m² = 420 mg/wk

b. Height 66 in, weight 210 lb, intersects 2.04 m²

200 mg/m²/wk × 2.04 m² = 408.00  400 mg/wk

6.Give cisplatin 30 mg/m²/day × 3 days.

Patient height: 70 in

Patient weight: 80 kg

What is the daily dose with:

a. square root method?

b. nomogram?

ANS:

a. 80 kg × 2.2 = 176 lb

30 mg/m²/day × 1.98 m² = 59.4  59 mg/day

b. Height 70 in, weight 80 kg, intersects 2.08 m²

30 mg/m²/day × 2.08 m² = 62.4  62 mg/day

7.Give cisplatinum 80 mg/m²/wk.

Patient height: 6 ft 2 in

Patient weight: 186 lb

What is the weekly dose with:

a. square root method?

b. nomogram?

ANS:

a. 

80 mg/m²/wk × 2.09 m² = 167.2 mg/wk

b. Height 74 in, weight 186 lb, intersects 2.10 m²

80 mg/m²/wk × 2.10 m² = 168  170 mg/wk

8.Give etoposide 120 mg/m²/wk.

Patient height: 74 in

Patient weight: 70 kg

What is the weekly dose with:

a. square root method?

b. nomogram?

ANS:

a. 70 kg × 2.2 = 154 lb

120 mg/m²/wk × 1.90 m² = 228 mg/wk

b.Height 74 in, weight 70 kg, intersects 2.06 m²

120 mg/m²/ wk × 2.06 m² = 247.2  250 mg/wk

9.Give Cytoxan 600 mg/m²/wk.

Patient height: 70 in

Patient weight: 85 kg

What is the weekly dose with:

a. square root method?

b. nomogram?

ANS:

a. 85 kg × 2.2 = 187 lb

600 mg/m²/wk × 2.04 m² = 1224 or 1225 mg/wk

b. Height 70 in, weight 85 kg, intersects 2.08 m²

600 mg/m²/wk × 2.08 m² = 1248  1250 mg/wk

10.Give Adriamycin 60 mg/m²/wk.

Patient height: 70 in

Patient weight: 80 kg

What is the weekly dose with:

a. square root method?

b. nomogram?

ANS:

a. 80 kg × 2.2 = 176 lb

60 mg/m²/wk × 1.98 m² = 118 mg/wk

b. Height 70 in, weight 85 kg, intersects 2.08 m²

60 mg/m²/wk × 2.08 m² = 124.8  125 mg/wk

11.Give vincristine 2 mg/m²/week.

Patient height: 62 in

Patient weight: 75 kg

What is the weekly dose with:

a. square root method?

b. nomogram?

ANS:

a. 75 kg × 2.2 = 165 lb

2 mg/m²/wk × 1.80 m² = 3.6 mg/wk

b. Height 62 in, weight 75 kg, intersects 1.78 m²

2 mg/m²/wk × 1.78 m² = 3.56  3.6 mg/wk

12.Give mitomycin 15 mg/m²/week.

Patient height: 65 in

Patient weight: 64 kg

What is the weekly dose with:

a. square root method?

b. nomogram?

ANS:

a. 64 kg × 2.2 = 140.8 or 141 lb

15 mg/m²/wk × 1.71 m² = 25.6 or 26 mg/wk

b. Height 65 in, weight 64 kg, intersects 1.75 m²

15 mg/m²/wk × 1.75 m² = 26.25  26 mg/wk

13.Give mitoxantrone 12 mg/m²/day × 3 days.

Patient height: 5 ft 8 in

Patient weight: 150 lb

What is the daily dose with:

a. square root method?

b. nomogram?

ANS:

a. 

12 mg/m²/day × 1.80 m² = 21.6 or 22 mg/day

b. Height 68 in, weight 150 lb, intersects 1.85 m²

12 mg/m²/day × 1.85 m² = 22.2  22 mg/day

14.Give cytosine arabinoside 100 mg/m²/day × 7 days.

Patient height: 5 ft 2 in

Patient weight: 130 lb

What is the weekly dose with:

a. square root method?

b. nomogram?

ANS:

a. 

100 mg/m²/day × 1.6 m² = 160 mg/day

b. Height 62 in, weight 130 lb, intersects 1.65 m²

100 mg/m²/day × 1.65 m² = 165 mg/day

15.Give methotrexate 3.3 mg/m²/day × 7 days.

Patient height: 72 in

Patient weight: 82 kg

What is the daily dose with:

a. square root method?

b. nomogram?

ANS:

a. 82 kg × 2.2 = 180.4 lb

3.3 mg/m²/day × 2 m² = 6.6 mg/day

b. Height 72 in, weight 82 kg, intersects 2.10 m²

3.3 mg/m²/day × 2.10 m² = 6.93  6.9 mg/day

16.Give prednisone 60 mg/m²/day × 7 days.

Patient height: 72 in

Patient weight: 84 kg

What is the daily dose with:

a. square root method?

b. nomogram?

ANS:

a. 84 kg × 2.2 = 184.8 or 185 lb

60 mg/m²/day × 2.06 m² = 123.7 or 124 mg/day

b. Height 72 in, weight 84 kg, intersects 2.10 m²

60 mg/m²/day × 2.10 m² = 126 mg/day

17.Give idarubicin hydrochloride 12 mg/m²/day × 3 days.

Patient height: 60 in

Patient weight: 60 kg

What is the daily dose with:

a. square root method?

b. nomogram?

ANS:

a. 60 kg × 2.2 = 132 lb

12 mg/m²/day × 1.59 m² = 19.1 or 19 mg/day

b. Height 60 in, weight 60 kg, intersects 1.60 m²

12 mg/m²/day × 1.60 m² = 19.2  19 mg/day

18.Give cytarabine 100 mg/m²/day × 7 days.

Patient height: 64 in

Patient weight: 65 kg

What is the daily dose with:

a. square root method?

b. nomogram?

ANS:

a. 65 kg × 2.2 = 143 lb

100 mg/m²/day × 1.7 m² = 170 mg/day

b. Height 64 in, weight 60 kg, intersects 1.69 m²

100 mg/m²/day × 1.69 m² = 169  170 mg/day

19.Order: streptozocin 1000 mg/m² in 100 mL D₅W over 2 hours

Patient’s height and weight: 5 ft 2 in and 210 lb

Drug available: streptozocin 1 g powdered vial, reconstitute with 9.5 mL NS; yields 100 mg/mL

a. What is the patient’s BSA (m²)?

b. What is the total dose?

c. How many milliliters should you prepare?

ANS:

a. 

b. 2.04 m² × 1000 mg/m² = 2040 mg

c. 

20.Order: methotrexate 3 mg/m² PO × 2 weekly

Patient’s height and weight: 5 ft 2 in and 130 lb

Drug available: methotrexate tablets 2.5 mg, 5 mg, 7.5 mg

a. What is the patient’s BSA (m²)?

b. What is the total dose?

ANS:

a. 

b. 1.6 m² × 3 mg/m² = 4.80 mg or 5 mg tablet twice a week

21.Order: sargramostim 250 mcg/m²/day, dilute in 50 mL and infuse over 2 hours

Patient’s height and weight: 5 ft 10 in and 215 lb

Drug available: sargramostim 500 mcg/mL

a. What is the patient’s BSA (m²)?

b. What is the total dose?

c. How many milliliters should you prepare?

ANS:

a. 

b. 2.52 m² x 250 mcg/m² = 630 mcg

c. 

22.Order: clofarabine 52 mg/m² daily and infuse in 250 mL D₅W over 2 hours

Patient’s height and weight: 5 ft 4 in and 115 lb

Drug available: 20 mg/20 mL

a. What is the patient’s BSA (m²)?

b. What is the total dose?

c. How many milliliters should you prepare?

ANS:

a. 

b. 1.53 m² × 52 mg/m² = 79.56 mg or 80 mg

c.